High Purity Human Growth Hormone Follistatin 344 For Muscle Strength

Cas No. N/A

Synonyms: FST, FS, Activin-binding protein

MW: 36KDa(35-40K)

Appearance: Sterile Filtered White lyophilized (freeze-dried)

Purity: >95%(SDS-PAGE)

Source: Expression in E. coli

Sequence:

MASMTGGQQM GRGSMGNCWL RQAKNGRCQV LYKTELSKEE CCSTGRLSTS WTEEDVNDNT LFKWMIFNGG APNCIPCKET CENVDCGPGK KCRMNKKNKP RCVCAPDCSN ITWKGPVCGL DGKTYRNECA LLKARCKEQP ELEVQYQGRC KKTCRDVFCP GSSTCVVDQT NNAYCVTCNR ICPEPASSEQ YLCGNDGVTY SSACHLRKAT CLLGRSIGLA YEGKCIKAKS CEDIQCTGGK KCLWDFKVGR GRCSLCDELC PDSKSDEPVC ASDNATYASE CAMKEAACSS GVLLEVKHSG SCNSISEDTE EEEEDLEHHH HHH.

Bacterial Endotoxins: < 5EU/mg

Introduction:

Follistatin 344 is a protein with 323 amino acids. Deficiency of the lysosomal enzyme acid α-glucosidase (GAA) can lead to massive accumulation of glycogen in lysosomes and autophagosomes of striated and smooth muscle, resulting in skeletal muscle weakness and cardiorespiratory failure. Follistatin 344, as an adjuvant, can stimulate muscle repair and improve motor function. Studies have shown that follistatin treatment stimulated significant muscle fiber hypertrophy in Pompe mice only when they were treated before 10 months of age, which imply that patients will be more likely to benefit from the muscle-enhancing molecules follistatin 344 if treated earlier, before irreversible muscle pathology has developed.

Follistatin is fascinating protein that can increase muscle mass beyond natural potential by suppressing myostatin. Scientists first identified follistatin while examining porcine (re: pig) follicular fluid in the ovaries.

Follistatin is naturally found in the skeletal muscle of almost all mammals with advanced or developed characteristics, such as humans, rodents, and cows. Follistatin is high in the non-essential amino acid cystine but unlike most proteins discussed in the fitness world, follistatin has carbohydrates attached to it.

Follistatin, specifically Follistatin 344 (FS344), quickly gained popularity in the bodybuilding community as a potential supplement to rapidly increase lean tissue mass. Another protein, follistatin-related gene (FLRG) acts on similar pathways as FS344 regarding its muscle building properties. Increased lean tissue mass could give a bodybuilder an advantage in a competitive setting and be the differentiating factor between first and second place.


Follistatin and Muscle Growth
Follistatin works by binding to and inhibiting transforming growth factor-β (TGF-β) peptides such as myostatin which is responsible for regulating and limiting muscle growth. It's also worth pointing out that myostatin may have a regulatory role in skeletal muscle fibrosis; too much myostatin can impair tissue function and cause chronic disease in vital organs, tissues, and bone marrow.
In additional to suppressing the degenerative properties of myostatin, follistatin also suppresses the pituitary gland synthesis and secretion of follicle-stimulating hormone (FSH). High FSH levels in men may indicate that testicles are not functioning correctly; this condition limits muscle growth, recovery, and normal hormonal function. [6] However, FSH levels that are too low can also negatively impact health and reproductive capabilities.

Whereas some myostatin inhibitors like Trichostatin A (TSA) require daily administration, increased levels of FS344 were observed up to 15 months after initial injection. [7][3] The lack of need for daily administration makes follistatin an attractive alternative for suppressing myostatin.

The recent increase in attention in the science community on follistatin and other myostatin inhibitors is primarily due to the desire to find an alternative means to treat muscle disorders; the most popular current option is androgen steroids which pose a number of side-effects and long-term health risks. At this point you might be wondering why follistatin use isn't more widespread in bodybuilders and other athletes. In the next section we will examine the current research on follistatin and whether it builds muscle mass.

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