Human rh-EGF Cosmetic Materials CAS 62253-63-8 Recombinant Streptococcal Protein G

Product Name: Recombinant Streptococcal Protein G (r-SPG)

Formulation: Lyophilized from 5 mM PB, pH 7.4.

Mol. Wt.: 28 kDa

Theoretical pI: 4.79

Resources: Escherichia coli (E. coli)

Purity: ≥95% by SDS-PAGE analysis

Storage Condition: -20^oC

Storage Duration: 3 years

Description:

Protein G is a bacterial cell wall protein expressing at the cell surface of some group C and group G Streptococcal strains and it can bind to the Fc region of immunoglobulin G (IgG) with a high affinity. Protein G binds to all IgG subclasses from human, mouse and rat species. It also binds to IgGs from guinea pig, rabbit, goat, cow, sheep, and horse. Protein G shows a broader range of binding to IgG subclasses than does staphylococcal protein A.

Some of the most important application areas for protein G are the isolation and purification or the removal of IgG from serum, the purification of monoclonal antibodies, and the isolation of immune complexes. It can also be applied for labeling. Protein G conjugates is commonly used as affinity adsorbents to purify immunoglobulins (antibodies) and immunoglobulin subtypes from serum, hybridoma ascites, tissue culture supernatants and other biological fluids.

In addition to the Fc receptor, intact protein G has membrane spanning regions as well as specific binding sites for albumin and for the Fab region of immunoglobins. The albumin and cell surface binding domains have been eliminated from r-SPG to ensure the maximum specific IgG binding capacity.