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synthetic human growth hormone,
hgh growth hormone
Cas No. N/A
Synonyms: MGF (Mechano Growth Factor)
Molecular Formula: C121H200N42O39
Bacterial Endotoxins: < 5EU/mg
Mechano Growth Factor (MGF) with sequence YQPPSTNKNTKSQRRKGSTFEEHK-NH2, is a novel splice variant of the insulin growth factor -1 (IGF-1), also known as IGF-1Ec in humans and IGF-1Eb in rodents. Studies have suggested that MGF plays a number of physiological roles because the failure in its expression may result to age-related loss of skeletal function. One included in its functions is its ability to become a potent neuroprotective as supported by the study that has shown functional copies of the MGF cDNA to be expressed in a plasmid vector which then protected facial neurons after nerve damage. One such failure is called sarcopenia. The appearance of MGF also initiates the upregulation of new protein synthesis.
MGF is a splice variant of the IGF gene which increases stem cell count in the muscle and allows for muscle fibers to fuse and mature. This is a process required for growth of adult muscle. Natural MGF is made locally and does not travel into the bloodstream. Synthetic MGF is water based and when administered intramuscularly, travels into the bloodstream. MGF is only stable in the blood stream for only a few minutes.
PEGylation is the act of attaching a Polyethylene glycol (PEG) structure to another larger molecule (in this case, MGF). The PEG acts as a protective coating and the theory here is that this will allow the MGF to be carried through the blood stream without being broken down.
Pegylated MGF is more bioavailable. Injected 2-3 times per week, it maintains effective concentration for a long period.
In bodybuilding this drug is used to accelerate muscle growth. Other effects of the drug include decrease of fat mass of the body, endurance increase, improvement of immune defenceand skin, bone strengthening, lowering of cholesterol level, accelerated recovery. Those who administered MGF declared that they experienced no side effects, which frequently occur with the use of other drugs for gaining body mass.
MGF has been used by bodybuilders and athletes for a few years already. After resistance exercise,IGF-1 is released within the muscle. Specifically, at this time, immediately following the mechanical use of a muscle, the IGF-I gene is spliced towards MGF which initiates hypertrophy and repair of local muscle damage. It does so both by activating muscle stem cells and satellite cells, but also via various other anabolic processes. (1) It differs from "regular" IGF-1 mainly due to it's C-Terminal sequenc.
MGF can initiate muscle satellite (stem) cell activation in addition to its IGF-Ireceptor domain which ithen in turn ncreases protein synthesis turnover, and therefore can if used correctly improve muscle mass over time.
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