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|Form:||Lyophilized Powder||Usage:||Becauty Purpose|
recombinant human epidermal growth factor,
FGF1, also known as acidic fibroblast growth factor (aFGF), is a growth factor and
signaling protein encoded by the FGF1 gene. It is synthesized as a 155 amino
acid polypeptide, whose mature form is a non-glycosylated protein.
Fibroblast growth factor protein was first purified in 1975, but soon afterwards
others using different conditions isolated acidic FGF, Heparin-binding growth
factor-1, and Endothelial cell growth factor-1. Gene sequencing revealed that this
group was actually the same growth factor and that FGF1 was a member of a family
of FGF proteins.
FGF-1 has no definitive signal sequence and thus is not secreted through classical
pathways, but it does appear to form a disulfide linked dimer inside cells that
associate with a complex of proteins at the cell membrane (including S100A13 and
Syt1) which then help flip it through the membrane to the exterior of the cell.
Once in the reducing conditions of the surrounding tissue, the dimer dissociates into
monomeric FGF1 that can enter systemic circulation or be sequestered in tissues
binding to heparan sulfate proteoglycans of the extracellular matrix. FGF1 can then
bind to and exert its effects via specific fibroblast growth factor receptor (FGFR)
proteins which themselves constitute a family of closely related molecules.
In addition to its extracellular activity, FGF1 can also function intracellularly. The
protein has a nuclear localization sequence (NLS) but the route that FGF1 takes to
get to the nucleus is unclear and it appears that some sort of cell surface receptor
binding is necessary, followed by its internalization and translocation to the nucleus
whereupon it can interact with nuclear isoforms of FGFRs. This is different from
FGF2 which also can activate nuclear FGFRs but has splicing variants of the protein
that never leave the cell and go directly to the nucleus.
|GHRP-6||IGF-1 LR3||Anastrozole (Arimidex)|
|CJC-1295 with DAC||IGF-1 DES||Boldenone|
|CJC-1295 NO DAC||Follistatin||Boldenone undecylenate (EQ)|
|Thymosin β4 (TB500)||EPO||Nolvadex|
|Melanotan-II (MT-II)||Tadalafil (Cialis)|
|Melanotan-I (MT-I)||SARM||Letrozole (Femara)|
|Triptorelin||LGD-4033 (Ligandrol)||Methenolone Acetate|
|GHRH||YK-11||Stanozolol Coarse (Winstrol)|
|Tesamorelin||Aicar||Stanozolol Micronized (Winstrol)|
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