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Home ProductsEGF Epidermal Growth Factor

Cosmetic Products EGF Epidermal Growth Factor Recombinant Human Fibroblast Growth Factor-basic rh-bFGF

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Just completed an order with Peter and his service is A+++. I have posted it elsewhere on the board. I did a gh serum test with his gh and it comes back more 30, crazy high score for 10iu.

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Was and am VERY, VERY impressed with Peter. Superb communication and overall customer service!! A+++++. will definitely be doing business with you.

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Cosmetic Products EGF Epidermal Growth Factor Recombinant Human Fibroblast Growth Factor-basic rh-bFGF

Cosmetic Products EGF Epidermal Growth Factor Recombinant Human Fibroblast Growth Factor-basic rh-bFGF
Cosmetic Products EGF Epidermal Growth Factor Recombinant Human Fibroblast Growth Factor-basic rh-bFGF

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Product Details:

Place of Origin: China
Brand Name: SGH
Certification: GMP, ISO9001,BRC,KOSHER
Model Number: bFGF

Payment & Shipping Terms:

Minimum Order Quantity: 10vials (1kit)
Price: Negotiation
Packaging Details: Discreet package or foiled bag or pack as customer's request
Payment Terms: T/T, Western Union, MoneyGram, Bitcoin
Supply Ability: 50000vials/Month
Detailed Product Description
Size: 10000iu/vial Synonyms: BFGF
Form: Powder Usage: Becauty Purpose
Color: White Storage: -20C
High Light:

recombinant human epidermal growth factor

,

recombinant egf

 
Mol. Wt.: 17.2 kDa
Resources: Escherichia coli (E. coli)
Purity: ≥95% by SDS-PAGE analysis
Endotoxin: <1.0 EU/µg protein
Storage Condition: -20oC
Storage Duration: 3 years
Biological Activity: The EC50, calculated by the dose-dependant proliferation of mouse BALB/c 3T3 cells is 0.25~1 ng/ml, corresponding to a specific activity of 1*106~4*106 units/mg protein.
 
Description:
Fibroblast Growth Factor-basic (bFGF), also known as FGF-2, is a heparin-binding member of the FGF superfamily of molecules. It plays important role in cell proliferation and differentiation associated with embryogenesis, tissue regeneration, wound healing, CNS development, angiogenesis, and tumor progression. Additionally, bFGF is a potent mitogenic agent for a wide variety of mesoderm-derived cells including BALB/c 3T3 fibroblasts, capillary and endocardial endothelial cells, myoblasts, vascular smooth muscle cells, mesothelial cells, glial and astroglial cells, and adrenal cortex cells.
Recombinant human bFGF in E. coli is a single, non-glycosylated, polypeptide chain containing 155 amino acids and having a molecular mass of 17.2 kDa.
 

FGF2, also known as basic fibroblast growth factor (bFGF) and FGF-β, is a growth

factor and signaling protein encoded by the FGF2 gene. It is synthesized

primarily as a 155 amino acid polypeptide, resulting in protein. However,

there are four alternate start codons which provide N-terminal extensions of 41, 46,

55, or 133 amino acids, resulting in proteins of 22 kDa (196 aa total), 22.5 kDa (201

aa total), 24 kDa (210 aa total) and 34 kDa (288 aa total), respectively. Generally,

the 155 aa/18 kDa low molecular weight (LMW) form is considered cytoplasmic and

can be secreted from the cell, whereas the high molecular weight (HMW) forms are

directed to the cell's nucleus.

Fibroblast growth factor protein was first purified in 1975, but soon afterwards

others using different conditions isolated basic FGF, Heparin-binding growth factor-

2, and Endothelial cell growth factor-2. Gene sequencing revealed that this group

was in fact the same FGF2 protein and that it was a member of a family of FGF

proteins. FGF2 binds to and exerts effects via specific fibroblast growth factor

receptor (FGFR) proteins which themselves constitute a family of closely related

molecules.


Function
Like other FGF family members, basic fibroblast growth factor possess broad

mitogenic and cell survival activities, and is involved in a variety of biological

processes, including embryonic development, cell growth, morphogenesis, tissue

repair, tumor growth and invasion.

In normal tissue, bFGF is present in basement membranes and in the subendothelial

extracellular matrix of blood vessels. It stays membrane-bound as long as there is no

signal peptide.

It has been hypothesized that, during both wound healing of normal tissues and

tumor development, the action of heparan sulfate-degrading enzymes activates

bFGF, thus mediating the formation of new blood vessels, a process known as

angiogenesis.

In addition, it is synthesized and secreted by human adipocytes and the

concentration of FGF2 correlates with the BMI in blood samples. It was also shown

to act on preosteoblasts – in the form of an increased proliferation – after binding to

fibroblast growth factor receptor 1 and activating phosphoinositide 3-kinase.

FGF2 has been shown in preliminary animal studies to protect the heart from injury

associated with a heart attack, reducing tissue death and promoting improved

function after reperfusion.

Recent evidence has shown that low levels of FGF2 play a key role in the incidence

of excessive anxiety.

Additionally, FGF2 is a critical component of human embryonic stem cell culture

medium; the growth factor is necessary for the cells to remain in an undifferentiated

state, although the mechanisms by which it does this are poorly defined. It has been

demonstrated to induce gremlin expression which in turn is known to inhibit the

induction of differentiation by bone morphogenetic proteins. It is necessary in

mouse-feeder cell dependent culture systems, as well as in feeder and serum-free

culture systems. FGF2, in conjunction with BMP4, promote differentiation of

stem cells to mesodermal lineages. After differentiation, BMP4 and FGF2 treated

cells generally produce higher amounts of osteogenic and chondrogenic

differentiation than untreated stem cells.However, a low concentration of bFGF

(10 ng/mL) may exert an inhibitory effect on osteoblast differentiation.

 

 

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