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Anti Estrogen Steroids Formestane Aromatizing Steroids CAS 566-48-3 For Breast Cancer

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Anti Estrogen Steroids Formestane Aromatizing Steroids CAS 566-48-3 For Breast Cancer

Anti Estrogen Steroids Formestane Aromatizing Steroids CAS 566-48-3 For Breast Cancer
Anti Estrogen Steroids Formestane Aromatizing Steroids CAS 566-48-3 For Breast Cancer

Large Image :  Anti Estrogen Steroids Formestane Aromatizing Steroids CAS 566-48-3 For Breast Cancer Get Best Price

Product Details:

Place of Origin: China
Brand Name: SGH
Certification: GMP, ISO9001,BRC,KOSHER
Model Number: 566-48-3

Payment & Shipping Terms:

Minimum Order Quantity: 10g
Price: Negotiation
Packaging Details: Discreet package or foiled bag or pack as customer's request
Payment Terms: T/T, Western Union, MoneyGram, Bitcoin
Supply Ability: 100kg/Month
Detailed Product Description
CAS NO: 566-48-3 Synonyms: Formestane
Form: Powder Usage: Loss Weight
Color: White Storage: -20C
High Light:

medicine steroids

,

anabolic steroid hormones

Product Description:

 

Formestane is often used to suppress estrogen production from anabolic steroids or prohormones. It also acts as a prohormone to 4-hydroxytestosterone, an active steroid which displays weak androgenic activity in addition to acting as a mild aromatase inhibitor.

Formestane (Lentaron) is a type I, steroidal aromatase inhibitor. It is used in the treatment of estrogen-receptor positive breast cancer in post-menopausal women. It is available as an intramuscular depot injection.

Formestane has poor oral bioavailability and as such is no longer popular as many orally active aromatase inhibitors have been identified.

 

Formestane was the first selective, type I, steroidal aromatase inhibitor used in the treatment of estrogen-receptor positive breast cancer in post-menopausal women. Formestane suppresses estrogen production from anabolic steroids or prohormones. It also acts as a prohormone to 4-hydroxytestosterone, an active steroid which displays weak androgenic activity in addition to acting as a mild aromatase inhibitor. It is listed as a prohibited substance by the World Anti-Doping Agency for use in athletes.

Formestane has poor oral bioavailability, and thus must be administered forthnightly (bi-weekly) by intramuscular injection. Some clinical data has suggested that the clinically recommended dose of 250mg was too low. With the discovery of newer, non-steroidal and steroidal, aromatase inhibitors which were orally active and less expensive than formestane, formestane lost popularity.

Currently, formestane (categorized as an anti-estrogenic agent) is prohibited from use in sports in accordance to the regulations of the World Anti-Doping Agency. It is not US FDA approved, and the intramuscular injection form of formestane (Lentaron) which was approved in Europe has been withdrawn.

Medical Application of Active Pharmaceutical Ingredients Formestane:
Formestane also known as lentaron,is an anti-cancer drug, it is primarily used for the treatment of postmenopausal women with advanced breast cancer, it is also effective in prostate cancer;

 

 

Product Applications:

Formestane is a second generation, irreversible, steroidal aromatase inhibitor. It inhibits the aromatase enzyme responsible for converting androgens to estrogens, thereby preventing estrogen production. Breast cancer may be estrogen sensitive or insensitive. A majority of breast cancers are estrogen sensitive. Estrogen sensitive breast cancer cells depend on estrogen for viability. Thus removal of estrogen from the body can be an effective treatment for hormone sensitive breast cancers. Formestane has been targeted specifically for the treatment of postmenopausal women. Unlike premenopausal women who produce most estrogen in the ovaries, postmenopausal women produce most estrogen in peripheral tissues with the help of the aromatase enzyme. Formestane, an aromatase inhibitor, can thus help to decrease the local production of estrogen by blocking the aromatase enzyme in peripheral tissues (ie. Adispose tissue of the breast) to treat hormone sensitive breast cancer.

 

 

COA

 

TEST ITEMS SPECIFICATION RESULTS
Description White or Almost White Crystalline Powder white powder
Identification A.B. Positive
Assay 97.0~103.0% 99.3%
Specific Rotation +101°~+105° +102.6°
Loss On Drying 1.0%max 0.27%
Melting Point 153~157°C 153.0~155.0°C
Organic Volatile Impurities meets the requirement. Conforms
Related Substances meets the requirement. Conforms
Residual Solvents meets the requirement. Conforms
Particle Size 100% ≤ 20 microns Conforms
Conclusion The specification conform with USP35 standard
 

 

 

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