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Cas No. 158861-67-7
Synonyms: GHRP-2 Acetate
Molecular Formula: C45H55N9O6
Bacterial Endotoxins: < 5EU/mg
Chemotherapy is the most effective treatment for most cancer patients. Many patients do not respond to therapy, and die of their disease. The cancer associated anorexia-cachexia syndrome is observed in 80% of patients with advanced stage cancer, and it is a very powerful prognostic indicator of poor outcome and poor quality of life. Moreover, this syndrome is also one of the major obstacles in cancer chemotherapy. Ghrelin is an orexigenic hormone which has been proposed to prevent anorexia. Therefore, this experiment is designed to determine whether addition of the Ghrelin agonist growth hormone releasing peptide 2 (GHRP-2) to cytotoxic therapy with 5-fluorouracil (5-FU) prevents anorexia associated with chemotherapy in cancer cachectic mice. Moreover, the chronic effect of GHRP-2 on reduced appetite and survival in this animal model were also been examined.
Thirty-three BALB/c female tumor-bearing mice were randomized to receive a solution including a). placebo; b) GHRP-2; c). 5-FU; d). 5-FU + GHRP-2. Ten of them received placebo solution. Food intake and survival were checked.
GHRP-2 is a synthetic agonist of ghrelin, the newly-discovered gut peptide which binds secretagogue receptor. Ghrelin has been shown to have two major effects, stimulating both GH secretion and appetite/meal initiation. GHRP-2 has been extensively studied for its utility as a growth hormone secretagogue (GHS). Animal studies have shown its effect on food intake.
GHRP2 growth releasing peptide2 therapy is considered one of a few medical means of reversing the effects of aging in adults deficient . This is because of the benefits resulting from the increased stimulation and secretion of human by the pituitary gland hypothalamus,axis HPA.
GHRP-2 is a synthetic releasing peptide that acts directly through the hormone secretagogue receptor.
It serves as a true human secretagogue to a lean body mass and in reduction of body fat or adiposity.
GHRP-2 is significant in stimulating an increase in pituitary gland's natural production of body's own endogenous
It is a therapy consisting of daily periodic sub-lingual dose.
GHRP-2 strongly increases the level of Factor 1 and gives ever better results when used with Growth Human Releasing Hormone (GRGH) in stimulating pituitary glands in secretion of human hormone.
GHRP-2 also helps in boosting hypothalamus system.
GHRP-2 is synergistic with GHRH due to secondary actions on hypothalamic neurons. The quantity of GH released by a living mammal to which GHRP-2 and GHRH are administered exceeds the combined release of each compound when measured when taken alone.
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