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Cas No. 946870-92-4
Synonyms: Insulin-Like Growth Factor-I LR3
Appearance: White Powder
Bacterial Endotoxins: < 5EU/mg
IGF-1 LR3, also known as Long R3 Insulin-like Growth Factor-I with 83 amino acids, is a human recombinant, single, non-glycosylated analog of IGF-I with the substitution of an Arginine (Arg) for the Glutamic Acid (Glu) at position 3, as well as a 13 amino acid extension peptide. This sequence change causes IGF-1 to avoid binding to proteins and allow it to have a much longer half life, around 20-30 hours. Due to this, it has been suggested that IGF-1 LR3 is more potent than the IGF-1 in many aspects such as increasing amino acid transport to cells, increasing glucose transport, increasing protein synthesis, decreasing protein degradation and so on.
IGF-1 belongs to the peptide family which has a same structure and size as insulin. It is a highly anabolic hormone that is released in the liver as well as in the peripheral tissues in response to the GH so that a new muscle could be built. The main work of IGF-1 is to build new muscle tissues by promoting nitrogen retention and protein synthesis. IGF-1 not only makes muscle fibers bigger, but also makes more of them. IGF-1 has potent effect on fat metabolism and helps the body to burn fat rapidly. It also improves mental functions such as reflexes and learning ability.
IGF-1 has a very sensitive and unstable property that's why it is used rarely because it has a very short term life of only 10 minutes. That's why a substitute of IGF-1 referred to as Long R3IGF-1 or IGF-1 LR3 is used. IGF-1 LR3 has longer life. IGF-1 life time is increased from 10 minutes to hours in IGF-1 LR3, so that the users can get away using a smaller amount of IGF-1 LR3 and does not have to use it as frequent. Long R3IGF-1 is in the form of lyophilized powder form or already reconstituted form.
What is the dosage for IGF-1LR3 ? Dose per injection: 50 mcg Injections per vial: 20 x 50 mcg dosages Example Amounts to Inject: If you use 1 ml of water for mixing then a 50mcg dosage = 0.05 ml (or 5 units on Insulin Syringe). For 2 ml of water for mixing then 50mcg = 0.10ml (or 10 units); if you have used 3ml of water for mixing, then 50mcg = 0.15ml (or 15 units).
IGF-1LR3 has a half-life of about 20-30 hours and is much more potent than base IGF-1. Since its half-life is about a day, the IGF-1LR3 will circulate the body, for around 24 hours, binding to receptors and activating cell communication that improves muscle growth and fat loss.
LR3 prevents glucose from entering into cells, which, in turn, forces the body to burn fat and not sucrose. In addition, its long half-life is desirable for another reason; site injections aren't necessary, as IGF-1LR3 will cycle the body binding to all muscle cells for about a day.