Skin Tanning and Sexity Ability Synthetic Growth Hormone Peptide Melanotan-II CAS NO 121062-08-6

Cas No. 121062-08-6

Synonyms: Melanotan-II

Molecular Formula: C50H69N15O9

MW: 1024.18

Sequence:

Ac-Nle-cyclo(-beta-Asp-His-D-Phe-Arg-Trp-epsilon-Lys-NH2)

Purity: >98%

Bacterial Endotoxins: < 5EU/mg

Introduction:

Melanotan-II, a cyclic heptapeptide homologue of the endogenous melanocortin peptide α-melanocyte-stimulating hormone (α-MSH) with sequence

Ac-Nle-cyclo[(beta-D)-H(d-F)RW-(epsilon-K)]-NH2, is a synthetic, non-selective

melanocortin receptor agonist with high affinity for MC1R, 3R, 4R, and 5R. It is used to prevent a sunlight-induced skin cancer by stimulating the skin tanning process. Studies have shown that melanotan II can actually reduce the body weight and the adipose tissue in the viscera of the mice and suppresse the caloric intake of the organism, which has implications in clinical applications of the possible treatment to reduce carbohydrate or calorie intake especially for the overweight and the obese. Melanotan II can also actually increased sexual desire and even concluded that it is a potent initiator of penile erection in men especially with that of erectile dysfunction.

GHRP-6 is a potent stimulator of natural release. GHRP-6 is a Hexa-peptide that promotes food intake by stimulating hunger and helps increase energy metabolism. Releasing Peptides, similar to GHRP-6, are most commonly used for treatment of (GH) deficiencies, eating disorders, obesity, etc. Research has shown that use of these Peptides increases lean muscle mass, strength, stamina and decreases body fat.

Application:

GHRPs are not simply surrogates of GHRH, instead GHRP-6 is an artificial activator of a separate newly discovered receptor called Secretagogue Receptor (GHS-R). Soon Ghrelin was discovered, the endogenous ligand that binds to the GHS-R. Both Ghrelin and all the synthetic compounds such as GHRP-6 were termed "Secretagogues" (GHSs). One side effect of GHRP-6 is a significant increase in appetite due to stimulating the release of Ghrelin, a peptide that is released naturally in the lining of the stomach that increases hunger and gastric emptying. Also, GHRP-6 causes stimulation of the anterior pituitary gland which causes an increase in release. The increased amounts of can cause the liver to secrete the , which improves the animal body's ability to burn fat and build muscle. Since GHRP-6 acts directly on the feedback loop which signals the inhibition release, GHRP-6 can re-stimulate the production Hormone.

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